Since then additional reports (3) of treated cases have appeared in the literature. To the Editor: —The report in The Journal of Nov. 17, 1951, by James A. Greene, entitled "Pituitary Dwarfism," presented conclusions which must be considered controversial in the light of our present knowledge of growth mechanisms and the role of the pituitary gland. The reason for failure in his other 4 cases is unexplained except by application of Collip’s (6) antihormone theory. This article is also available for rental through DeepDyve. The causes may be congenital (rare) or acquired. EUR €27.00
If you originally registered with a username please use that to sign in. 9 sibs are affected by pituitary dwarfism. Oxford University Press is a department of the University of Oxford. Features of Cytologically Indeterminate Molecularly Benign Nodules Treated with Surgery This work was performed under a research grant from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.Present address: Peter Bent Brigham Hospital, Boston 15, Massachusetts.M. Studies of target-gland function indicated, apart from growth hormone and gonadotropin deficiency, impairment of thyroid and/or adrenocortical activity in 75 per cent of the cases as judged by serum cholesterol and protein-bound iodine levels, water diuresis, insulin sensitivity and 17-hydroxycorticoid excretion. Extreme shortness in humans with proportional body parts usually has a hormonal cause, such as growth-hormone deficiency, once called pituitary dwarfism. Instead, the dwarfs suffer from a wide range of clinical manifestations. You could not be signed in. The management and available treatment of hypopituitary dwarfism is outlined and early substitution therapy with sex hormones is urged (though not before the usual age of puberty) once the diagnosis is reasonably certain.Most users should sign in with their email address. Pituitary dwarfism can be categorized as either congenital (present at birth) or acquired. Seven patients had neoplasms in the region of the sella turcica, whereas 19 had idiopathic pituitary insufficiency. In at least 6 of these, growth exceeded the normal increment, and in all it materially exceeded that anticipated on the basis of previous development. Twenty-six cases of pituitary infantilism followed past the age of puberty were analyzed with regard to etiology, sex incidence, time of onset of growth retardation, and frequency of impairment of target-gland function, in an attempt to ascertain whether the diagnosis of pituitaiy insufficiency could have been established before the time of expected sexual maturation. The youngest of the affected sibs has been successfully treated with human growth hormonefor morethantwo years. To purchase short term access, please sign in to your Oxford Academic account above.
NAFLD and NASH in postmenopausal women: implications for diagnosis and treatment Since then additional reports (3) of treated cases have appeared in the literature. Treatment of human pituitary dwarfism resulted in satisfactory growth. Don't already have an Oxford Academic account?
A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia In at least 6 of these, growth exceeded the normal increment, and in all it materially exceeded that anticipated on the basis of previous development. • Dwarfism’s treatments dont increase stature but may alleviate problems caused by complications • Surgical procedures that may correct problems with bones in people with disproportionate dwarfism • Some people with dwarfism elect to undergo limb-lengthening surgery. 2 of these patients havegoneinto spontaneous puberty, and the third probably will. Two disorders, achondroplasia and growth hormone deficiency, are responsible for the majority of human dwarfism cases. There were 5 females and 2 males among the subjects with tumors, but only 1 female among the 19 patients with idiopathic hypopituitarism. To purchase short term access, please sign in to your Oxford Academic account above. You do not currently have access to this article.
Turner (5) detailed his treatment of 9 cases of endocrine growth deficiency. The time at which growth retardation became manifest varied but tended to be after the age of 3, and showed itself earlier in the idiopathic cases than in the tumor cases. Search for other works by this author on: USD $35.00 Schaefer (4) reports treatment of 11 cases. Oxford University Press is a department of the University of Oxford. NELSON M. TAYLOR, PITUITARY DWARFISM: TREATMENT WITH GROWTH HORMONE, Evans and Long (1) first reported, in 1921, the preparation of an anterior pituitary extract which produced gigantism in normal rats and growth in hypophysectomized rats. If you originally registered with a username please use that to sign in. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem Pituitary dwarfism is a disease resulting when the body fails to use the pituitary growth hormone GH.